Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. The evidence is solid. Fluvoxamine is also an One Silicon Valley entrepreneur thought he could beat the odds. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. Worst case, if we ignore all additional evidence so the average is a 60% pass rate. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. The web price charge of skirsch.io . Do they sell it anywhere? Fluoxetine is just as effective. But how many did it help? If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. Early research suggests that fluvoxamine, an FDA approved medication for depression and obsessive compulsive disorder, can be an effective early treatment for COVID-19. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. Fluvoxamine was reportedly added to just 2 practice guidelines (Ontario and Johns Hopkins). Steve Kirsch Executive Director at COVID-19 Early Treatment Fund (2020-present) Author has 176 answers and 1.7M answer views Updated 1 y Both. - Quora, Heres presentation I gave at the re-open California Conference on January 9,2021: How to fix the problemHow to fix the problem Steve Kirsch Executive DirectorCOVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008Google Docs[https://docs.google.com/presentation/d/1-A4y78wv3tTPmVu57FOabY6j-MJbPwMGojKwZfaCkAs/. Ive used it personally at 50mg twice a day and experience no adverse events at all. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. Don't underestimate the virus. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. Compulsive hand washing? It does not matter how many lives will be saved. It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). After boosting unproven covid drugs and campaigning against vaccines, Steve Kirsch was abandoned by his team of scientific advisersand left out of a job. Stopping the meds will return you to your normal self. If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). Kirsch said that his attempts to promote fluvoxamine are being curtailed. Thanks for working tirelessly to help others. There are 4 outpatient studies that have been done (2 at WashU (see. Since making a fortune as the founder of Infoseek, an early search engine that was the Google of its day, Kirsch has spent tens of millions of dollars fighting humanitys biggest threats. This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. Drug interactions should be checked for. In September, he resigned as CEO and gave up his board seat. Steve Kirsch -Executive Director at COVID-19 Early Treatment Fund Ivermection study - One .2mg/kg dose a week for prevention "100% success rate whereas those doctors taking placebo had a 59%% infection rate not a typo 237 of 400 docs on placebo got infected vs. 800 docs on Ivermectin none got infected" Antivirals These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. So you can address your OCD and if you get COVID, youll can up the dose. Im not going to make the same mistake again.. It is very important to educate doctors because most people rely on their doctors for advice. The babys brain was split in half, and it was just covered with blood. All have had a 100% success record in keeping their patients out of the hospital. Physicians who use the drug for COVID now swear by it. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. Compulsive fiddling with your mask? It was so bad you couldnt even see the babys body through all the blood, Kirsch said. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. And that is what has allowed Kirsch, and people like him, to become so influential. He started a covid-19 vaccine company. An approach that promised to democratize design may have done the opposite. Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. just like ivermectin). They all promised me when fluvoxamine passed Phase 3 trials, nearly everyone would use it. Most doctors wont use it until NIH greenlights it, no matter what the science says. You can use fluoxetine as well (aka Prozac). Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. From the French observational data (see the very last page), it appears that the biggest effect is limiting serotonin release (any SSRI will do that). As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. I couldnt tell I was on the drug. fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. ). The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. This drug can save your life but you have to ask for it! While combining the results of several well-designed trials can strengthen an argument or unearth patterns unseen in smaller samples, a meta-analysis is just the sum of its parts; any single well-done experiment is more useful than combining the results of several poorly done ones. FDA official fluvoxamine rejection. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. Hes adept at debate, rapidly shifting the premise of a conversation to put the other person on the back foot. We need to keep people out of the hospital in the first place. He started 7 high tech companies, two with billion dollar market caps. The medical community did nothing (with a few exceptions like Dr. Seftel). Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. Comparison with molnupiravir. Quick Summary . I will . People who report not tolerating the drug are typically prescribed too high a dose. The infectious disease scientists lied to me. If you cant lay off the java, then try fluoxetine (Prozac). Medicine isnt about saving lives anymore. . If you cant get a prescription for COVID, then perhaps you have OCD? What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. If you take fluvoxamine, please avoid caffeine while on the drug. It was not compatible with his position as CEO to continue taking a very public stance on the vaccines, Richard Char, M10s general counsel, told me. February 17, 2021. . In short, a lot of mumbo jumbo. Mr. Steve Kirsch - A philanthropist and former Silicon Valley tech executive. Earlier that month, Seftel had heard about fluvoxamine during a presentation by tech entrepreneur Steve Kirsch, whose COVID-19 Early Treatment Fund supports research on existing drugs that could . People who report not tolerating the drug are typically prescribed too high a dose. Note that some of these articles are inaccurate. He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. The antidepressant fluvoxamine, which is generic, but sometimes sold under the brand name Luvox, is a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). So take the lowest likely effect size * 60% success rate and you are looking at an expected 45% reduction in death which is clearly better than a 0% reduction. He has been a medical philanthropist for more than 20 years. Im taking low dosage Fluvoxamine as part of a multi-drug FLCCC protocol to alleviate some mild brain fog. upcoming events, and more. This give another 50% of benefit. Thats pretty typical, but your mileage may vary. Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. The medical community doesnt care about saving lives. Almost 2.5 million people signed up to Dr. B with the promise of getting leftover vaccines. She understands complex, politicized pandemicsshe was one of the first clinicians to specialize in HIV/AIDS, and she sat on the FDA advisory panel that approved the first antiretroviral drug. Doctors have no excuse for not prescribing. We didnt come up with better mouse technology than Microsoft did. this is NOT about the science. Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. MD, MPH; Steven C. Marcus, PhD. , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. 19 In addition, several . Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. @stkirsch. sorry about that. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. Fluvoxamine, COVID, pandemic, . The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! Another CETF grant, though, yielded far more exciting results. just like ivermectin). Is that really true? That was a lie. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Or just depression about the vaccine mandates? Compulsive fiddling with your mask? Doctors who have used fluvoxamine in the US and other countries swear by it. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. An MIT Technology Review investigation recently revealed how images of a minor and a tester on the toilet ended up on social media. Links to evidence about fluvoxamine including the public data repository. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. As noted before, the repository has a link to the 1 hour serotonin lecture. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. Everyone is stunned, but nobody is surprised. Drug researchers at Washington University in St. Louis reached out to Kirsch looking for $67,000 to finish a very smallbut placebo-controlledtrial. This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! (Siliciano did not respond to requests for comment for this article.). Fluvoxamine has at least a 30% hospitalization and death benefit. I took it myself at that dosage and noticed zero side effects. In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. The medical community doesnt care about saving lives. Thats why they didnt even fund the fluvoxamine trial, he told me. Steve Kirsch. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. Thats what creates some of these heroes.. 36m "We found Fauci was the most highly compensated federal employee. If you take fluvoxamine, please avoid caffeine while on the drug. . $1M reward: Do we need more data re: Fluvoxamine for COVID-19? Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. The paramedics will think you are on drugs. Less than a week later, David Seftel read about the Lenze trial, and ignored the JAMA advice. . But a panel of key opinion leaders from the NIH, CDC . Steve Kirsch is looking for an explanation for 171,000 excess deaths. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. It was completed in August. There may be a depression of libido while on drug, but since the drug is taken on acute basis, this is only temporary and it reverses once the drug is stopped. The combined p value of the two studies is <.0001. We should not wait for the Phase 3 RCT. But they dont want their names used. . Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . And, according to three members of CETFs scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for covid. Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. Steve Kirsch is a Silicon Valley philanthropist. . Always be self aware when using fluvoxamine. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). Some people report mild nausea while on the drug (stops when stop the drug). This looks ominous, but it harmless. His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. No more. Items included in the Television News search service. . Now they turn to Rust. saying that the per-protocol analysis was arbitrary and other excuses. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. Please. He thinks # killed by vax could be anywhere between 0 and 150K people dead.. Steve Kirsch is baffled. There is an executive summary below, but the most important thing is that top infectious disease docs who have looked at all the evidence (including the two clinical trial results) believe the effect size is 75% or more in reducing the hospitalization rate. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. Server IP address resolved: Yes Http response code: 200 Response time: 0.27 sec. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. At the beginning of the COVID-19 pandemic, Steve Kirsch created the COVID-19 Early Treatment Fund (CETF) to finance trials of off-patent drugs in an attempt to find a potent treatment that had been staring us in the face. Theres nothing there.). While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. YouTube , , , fluvoxamine, , , , , , , , , , This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. I see it all the time on social media, Morris told me. You will be wired for 24 hours if you dont heed my advice. BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. Be warned!. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. Waiting months for the phase 3 trial to complete is nuts. Its whether Merck can make a killing that matters. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. Personal life. Completely avoid caffeine, alcohol, tylenol, and benadryl.